The Life Scientific: AP De Silva
Pioneering photochemist AP De Silva on building molecular photo sensors for urgent medical diagnosis and to compute activity inside cells and tissues.
From humble beginnings in his native Sri Lanka, to a more than 40 year academic career at Queen鈥檚 University Belfast, Prof. AP (Amilra Prasanna) De Silva鈥檚 research into molecular photosensors has led to a pioneering career in that鈥檚 evolved from chemistry to medical diagnostics on one hand, to information processing on the other. Prof. De Silva challenged cultural expectations and overcame the lack of opportunities in chemistry that were available in Sri Lanka in the early 1970s. He first moved to Belfast to pursue research in photochemistry at Queen鈥檚 University. Inspired by his grandmother鈥檚 struggle with high blood pressure he engineered a unique sodium photosensor by marrying fluorescent molecules with chemical receptors. As a result of his international collaborations, a commercial, portable sensor was developed to detect salts and minerals in the blood. Its speed of analysis has since saved countless lives and improved healthcare around the world. AP talks to Jim Al-Khalili about his passion for engineering molecules and how his photochemical innovations have since crossed into computer science. They鈥檝e been developed to perform molecular computations far inside the human body - where silicon microchips fear to tread. A new deeper understanding of life inside our tissues and cells beckons.
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