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According to the Guinness Book of World Records, TB is humanity’s oldest contagious disease. It has become something of an afterthought in rich nations, but remains the world’s most deadly infectious disease. In 2024 it killed more than 1.2 million people. South Africa has one of the highest TB burdens in the world, but it has also developed one of the most sophisticated scientific ecosystems for the study of the disease. Clinical trials conducted in the country have been crucial to the innovation of TB treatments, vaccines, diagnostics and prevention strategies. Much of the funding for this research comes from American institutions. But since early 2025, streams of that money have been withdrawn due to a series of decisions by the Trump administration. For Crossing Continents, Sandra Kanthal visits Cape Town and discovers the story of two intertwined landscapes: the people in local communities struggling with the burden of tuberculosis, and the scientific institutions embedded in them trying to tackle the disease - and why at the moment both are struggling. Presenter/Producer: Sandra Kanthal Producer in South Africa: Isa-Lee Jacobson Editor: Penny Murphy Sound Design: James Beard Production Coordinator: Katie Morrison