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Discovery of the single gene mutation that makes mosquitoes resistant to exisisting insecticides opens the posibility for developing new, targetted insecticides to prevent mosquito-borne diseases like malaria and west Nile virus. It is the 50th anniversary of a controversial experiment by Stanley Miller to re-create the basis of life in a test tube. How does El Niño move around the Pacific? What owls can teach us about aeroplane design.